This course is focused on the fundamental aspects of proteins, including their chemical and physical structure, synthesis and stability, and function. In addition to these fundamentals, classical and contemporary methods used to purify and analyze proteins, and determine or predict their structure will be covered. Current topics in protein structure and proteomics will also be examined.
1. Review of amino acid structure
2. Amino acid biosynthesis
Review of nitrogen metabolism
Biosynthesis of nonessential amino acids starting from different precursors
Synthesis of molecules derived from amino acids
3. Primary structure
4. Secondary structure
5. Supersecondary structure
6. Tertiary structure
7. Quaternary structure
8. Assisted folding
9. Methods to determine protein structure
Protein data bank
Other protein databases
11. Enzyme kinetics
12. Protein regulation
13. Membrane proteins
Methods of Instruction
Instruction will be a combination of lecture, guest lectures, seminar, in-class activities and student presentations.
Means of Assessment
Evaluation will be carried out in accordance with Douglas College policy. The instructor will present a written course outline with specific evaluation criteria at the beginning of the semester. Evaluation will be based on the following:
|Quizzes and/or assignments
After completion of this course, students will be able to:
1. Identify the structures of the common amino acids in proteins
2. Describe the biosynthesis of the common amino acids in proteins
3. Describe the common elements found in primary, secondary, tertiary and quaternary structure
4. Explain the role of molecular chaperones
5. Explain the different methods used to identify protein structure
6. Describe the typical Michaelis-Menten kinetics of enzymes, and also describe the effects of enzyme inhibitors
7. Explain protein regulation, using specific examples
8. Analyze the structure and function of membrane proteins
Course Guidelines for previous years are viewable by selecting the version desired. If you took this course and do not see a listing for the starting semester/year of the course, consider the previous version as the applicable version.
Below shows how this course and its credits transfer within the BC transfer system.
A course is considered university-transferable (UT) if it transfers to at least one of the five research universities in British Columbia: University of British Columbia; University of British Columbia-Okanagan; Simon Fraser University; University of Victoria; and the University of Northern British Columbia.
For more information on transfer visit the BC Transfer Guide and BCCAT websites.
If your course prerequisites indicate that you need an assessment, please see our Assessment page for more information.