This course involves four hours per week of classroom instruction and three hours per week of laboratory activity. Classroom work will include lectures and tutorials, and is integrated with textbook, scientific journal readings and problem assignments. The laboratory work is designed to complement the theory content of the course.
The major topics in the course include the following:
1. Mechanics of Inheritance, including:
- mitosis
- meiosis
- life cycles
- crossing-over
2. Mendelian Inheritance, including:
- monohybrid inheritance
- dihybrid inheritance
- allelic relationships
3. Probability and Statistics (including Chi Square test)
4. Non-Mendelian Inheritance, including:
- linkage
- sex-linked inheritance
- sex-influenced inheritance
- sex-limited inheritance
- holandric inheritance
- multiple allelism
- multigenic inheritance
- extra-chromosomal inheritance
5. Chromosome mapping
6. Sex determination and sex differentiation
7. Mutation and mutagenesis
8. Nucleic acid structure and replication
9. Protein Synthesis
10. Genetic control mechanisms
11. Microbial genetics
12. Viral genetics
13. Population genetics
14. Evolution
Upon completion of this course, students will be able to demonstrate an understanding of the principles of classical and modern genetics, including being able to:
1. Describe the physical basis of heredity.
2. Describe the experimental basis of Mendelian inheritance.
3. Describe sex determining mechanisms in a wide variety of organisms.
4. Describe non-Mendelian inheritance, including linkage, sex-linkage, sex-influenced inheritance, sex-limited inheritance, holandric inheritance, multiple allelism, multigenic inheritance, and extra-chromosomal inheritance.
5. Interpret pedigrees to determine modes of inheritance of genetic anomalies in humans.
6. Derive chromosome maps by a variety of techniques, including the analysis of:
- testcross data in higher organisms
- tetrad analysis in fungi
- conjugation experiments in bacteria
7. Describe the cytological and biochemical basis of mutation and mutagenesis.
8. Describe the structure, replication, and functions of nucleic acids.
9. Describe the process of protein synthesis and the control of protein synthesis in bacteria and higher organisms.
10. Describe the genetic control of metabolism.
11. Describe the genetics of populations, including Hardy-Weinberg equilibrium, genetic drift, the effects of selection on allele frequencies and the evolutionary implications of population genetics.
12. Perform and interpret genetic experiments with a variety of organisms.
13. Describe the genetic basis of evolutionary theory
14. Use general principles of genetics to discuss current issues.
TYPE OF EVALUATION POINTS
Class tests & assignments 10-20
Mid Term Exam 15-35
Final comprehensive Exam 35
Essay 5-10
Lab reports (6) 10-15
TOTAL 100
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Grades: A+ 95-100 A 90-94 A- 85-89 B+ 80-84 B 75-79 B- 70-74
C+ 65-69 C 60-64 C- 55-59 P 50-54 F 0-49
Textbooks and Materials to be Purchased by Students
Snustad, P.D., and Simmons, M.J., 2000. Principles of Genetics (2nd Edition).
New York: John Wiley & Sons Inc.
BIOL 1210 with C- or better grade or permission of instructor