Leon J. Guppy
About
Instructor teaching:
- General biology
- Anatomy and physiology
- General pharmacology
- Genetics
- Molecular biology
- Microbiology
Education and credentials
- PhD, London
- MSc, London
- BSc, British Columbia
Research summary
Research interests:
- Alcoholism
- Drugs of abuse
- Cardiovascular biology and pharmacology
- Ion channel pharmacology
Publications and other research outputs
- Douglas College Human Anatomy & Physiology II
- Targeting ischemic ventricular arrhythmias
- Adaptation in membrane Ca2+ channels as a basis for alcohol-related pathology
- Chronic exposure to ethanol increases dihydropyridine‐sensitive calcium channels in excitable cells
- Binding characteristics of the calcium channel antagonist [3H]-nitrendipine in tissues from ethanol-dependent rats
- Time course and genetic variation in the regulation of calcium channel antagonist binding sites in rodent tissues during the induction of ethanol physical dependence and withdrawal
- Effects of anipamil, a long acting analog of verapamil, in pigs subjected to myocardial ischemia
- The antihypertensive effects of the Jamaican Cho-Cho (Sechium edule)
- Unravelling mechanisms underlying ischaemic arrhythmias - the importance of models
- Effects of prolonged exposure to ethanol in vivo on functional parameters and sensitivity to nitrendipine in the isolated rat heart
- Effect of calcium, bay K 8644, and reduced perfusion on basic indices of myocardial function in isolated hearts from rats after prolonged exposure to ethanol
- Increased sensitivity to damaging effects of hypoxia and anoxia of isolated hearts from rats after prolonged exposure to ethanol: Apparent protection by nitrendipine
- Damaging effects of the calcium paradox are reduced in isolated hearts from ethanol-dependent Rats: Paradoxic effects of dihydropyridine drugs
- Functional pharmacology: the drug discovery bottleneck?